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Vitamin E inhibits ferroptosis by preventing the cisplatin-induced decline in the renal antioxidant defense system or by its direct free radical-scavenging activity [183]
Secondly, mitochondria regulate redox balance, with balanced ROS production maintaining ECM integrity by modulating matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), while excessive mitochondrial reactive oxygen species (ROS) can lead to collagen fragmentation and elastin degradation [13,14,15]
(Ed.), Uptodate
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Qi X, Ng KT, Lian Q, Li CX, Geng W, Ling CC, Yeung WH, Ma YY, Liu XB, Liu H, et al
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