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2.5 Clinical case Female patient, 60 years old, was admitted to the hospital in a poor condition, with signs of cognitive disorders

In the early 1950's, Earl Sutherland and Christian de Duve demonstrated that pancreatic glucagon production was abolished when the function of islet -cells was compromised by treatment with either cobalt or synthalin A but was preserved upon alloxan-induced impairment of the exocrine pancreatic acinar and islet -cells [14,15]

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Moreover, GLP-1R is found in the heart and blood vessels and is beneficial in heart rate, vascular endothelium, atherosclerosis, and hypertension [58, 59]