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By activating CRF receptors in the brainstem and limbic system, CRF strengthens pain transmission pathways, leading to pronounced heartburn and chest pain even with mild stimulation

Its design refines the natural peptide hormone amylin, modifying the structure to overcome inherent limitations, such as instability and a short plasma half-life

drive to eat, not willpower: Martin Nat Med 2025

Mildly hyperprolactinemia may cause infertility due to luteal insufficiency, even in women with regular menses (16)

An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder