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Nevertheless, some compounds, including 18-glycyrrhetinic acid and luteolin, are reported to modulate broad metabolic networks, but these findings often derive from untargeted metabolomics in complex in vivo systems, failing to pinpoint primary molecular targets or establish causal relationships

Angermayer calls this humanmaxxing

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Adebayo GI, Williams J, Healy S (2007) Aspirin esterase activity Evidence for skewed distribution in healthy volunteers