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Many patients find relief through non-pharmacologic strategies: reducing the pace of weight loss via slower dose escalation, incorporating strength training to stabilize joints, maintaining adequate protein intake to preserve muscle mass, and using anti-inflammatory approaches like omega-3 supplementation or physical therapy

Pain scores also declined in treated patients, while they increased in the control group

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Glutathione S transferase (GST) is the main intracellular antioxidant synthetized by Glutamate-Cysteine ligase and glutathione synthase, as demonstrated by Chen et al., 2007 in a study including with Gclc Knockout mice, which developed steatosis in very early ages [65]

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