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To put this in perspective, the FDA approval of Ozempic was based on evidence from seven clinical trials with over 4,000 participants in 33 different countries

Semaglutide mimics the action of incretin hormones, particularly GLP-1 (glucagon-like peptide-1), a hormone that is naturally produced in the gut in response to food intake

This supports the conclusion that it is specifically the glucagon receptor, present in retatrutide but not in tirzepatide, that drives the larger heart rate signal

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GIP and GLP-1/GIP receptor agonists GIP receptors have been found in the pancreas, on adipocytes, in the hypothalamus, gastric mucosa, heart, and bone