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Pregnancy and breastfeeding are not recommended

Both are FDA-approved for chronic weight management in adults who meet certain criteria, but tirzepatide targets both GIP and GLP-1 pathways, while semaglutide targets GLP-1

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To determine a causal role between senescent cells and tauopathy, we administered intermittent (once every two weeks) senolytic therapy (D+Q) to tau transgenic mice between the ages of 2023 months old with already present tau pathology, neurodegeneration, inflammation and brain atrophy (35)

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