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PLGA is a hydrophobic polymer, which is more suited to encapsulate hydrophobic rather than hydrophilic agents via two general methods 4 : (1) Nanoprecipitation, in which PLGA and agents to be encapsulated are dissolved in a good solvent and then co-precipitate into nanoparticles upon addition into a non-solvent for both

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Biocatal Agric Biotechnol 36:102150 El-Katony TM, Nour El-Dein MM, El-Fallal AA, Ibrahim NG, Mousa MM (2020) Substratefungus interaction on the enzymatic and non-enzymatic antioxidant activities of solid state fermentation system