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Do not rush dose escalation The standard escalation schedule exists for a reason

The current crisis leaves patients and healthcare providers in a bind, with the drugs benefits hanging in the balance

Like Tirzepatide, Retatrutide will likely follow a gradual dose escalation approach, starting low and increasing every few weeks based on tolerance and response

[Perkovic FLOW, NEJM 2024] STEP 1 Extension (Discontinuation Data) After stopping semaglutide, participants regained approximately two-thirds of lost weight within one year

[3] Agents that can trigger exacerbations include viral infections, emotional stress, pregnancy, heat exposure, allergic reactions to foods, and irritation or provocation by environmental agents