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Those who stop after two weeks and declare it ineffective have not given the mechanism time to work

So not something within the ovary or a lack of the pituitary to make LH or FSH, but a deficit of the hypothalamus to promote LH and FSH and the downstream hormones, testosterone and estrogen

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Outcomes Our primary outcome was a composite outcome encompassing five major clinical events: all-cause hospitalization, all-cause mortality, major adverse cardiovascular events (MACEs), major adverse kidney events (MAKEs), major adverse liver outcomes (MALO), and hepatocellular carcinoma (HCC)

doi:10.1016/s0167-0115(03)00120-4 5