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Protective Effect of Glutathione against Oxidative Stress-induced Cytotoxicity in RAW 264.7 Macrophages through Activating the Nuclear Factor Erythroid 2-Related Factor-2/Heme Oxygenase-1 Pathway

Systemic and topical administration work through different pathways, potentially complementing each other

MEF L929 cells were seeded in 96-well plates (1 10^5 cells/well) and cultured for 24 h

A study investigating lactoferrin revealed a correlation between decreased lactoferrin levels, diminished expressions of regulators of ferroptosis like glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11), and elevated blood glucose levels in GDM patients, thereby providing evidence for the involvement of ferroptosis in the pathophysiology of GDM [75]