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showed that during intestinal inflammation, the GVB is disrupted, thus determining a state of bacterial product translocation and systemic inflammation, eventually leading to the propagation of inflammation to the brain, while the vascular barrier in the choroid plexus shuts down, helping protect the brain from inflammation but also potentially impairing some brain functions and causing anxiety [42]

The titration schedule from TRIUMPH-4 started all participants at 2 mg once weekly

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Successful treatment of infection will also lower oxidative stress

Simm, Redox Biology Role of advanced glycation end products in cellular signaling, Redox Biol