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Clinical treatments of CKD is mainly focused on symptomatic and supportive treatment, including inflammation inhibition, regulation of acid-base balance and electrolyte disorders, and enhancement of renal blood circulation [2]

Additionally, the inhibition of GPX4 was thought to accelerate uncontrolled lipid peroxidation, leading to cell death, whereas GPX4 and ACSL4 double knockout cells had significantly prolonged overall survival (Yang et al., 2016)