Luteolin, at a dose of 20 M, had a greater inhibitory effect on histamine release (60%) than kaempferol (50%) at 100 M [46,54]
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Hence, its use with some drugs that are also metabolized with CYP1A2 is associated with the risk of increasing their blood concentrations and prolonging their duration of action [75,78]
So states and employers are pulling coverage not because the drugs don't work, but because no one built the infrastructure to know who actually needs them
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