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Overall, irreparable damage to membranous organelles, spindle microtubules, cellular DNA, and the heat shock system itself leads to profound dysfunction of gametes and embryos and even apoptotic cell death, all of which adversely impact fertility (84, 85, 107, 109, 110, 152, 153)

Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency

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This perspective aims to frame these insights and highlight their implications for future research and therapeutic development