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Fermented foods and prebiotic compounds support a healthy gut microbiome, which influences GLP-1 production through the gut-brain axis

Instead, they may elevate the risk of pancreatitis, which can be managed by ensuring gradual weight loss and appropriate dosing of the medication

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& Bjrklund, A.) 99132 (Elsevier, 2017)

In the early stages of DKD, increased hyper-reabsorption and gluconeogenesis expose proximal tubular cells to hypoxia, resulting in mitochondrial dysfunction, increased oxidative stress and tubular injury ( Mitochondria is the primary organelle of in PTECs that is modulated to oxidative stress and hypoxic injury in the diabetic state ( Although there are a large number of in vitro and in vivo studies investigating the mechanism of hypoxia-induced renal tubular damage, due to the lack of non-invasive means, there are few clinical studies that have evaluated renal hypoxia in detail