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One six-month, randomized, double-blinded, placebo-controlled trial found that taking oral glutathione at either 250 or 1,000 mg/day led to significant increases in the body stores of glutathione in a dose-dependent manner

doi:10.1371/journal.pone.0148316 33SouayahN, Ajroud-DrissS, SanderHW, BrannaganTH, HaysAP, ChinRL

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Beyond its direct impact, CB-839, when combined with immunotherapy, has been shown to inhibit the clonal expansion and activation of CD8+ T cells in NSCLC, thereby counteracting the adverse effects associated with PD-1 immunotherapy (89)