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For CY 2026, we proposed to continue to assign HCPCS code C8001 to APC 5721 which has a proposed rate of around $132

That adds complexity without changing reimbursement

The mechanism is not fully established, but the preservative may offer a mild stabilizing effect on certain peptide bonds

Copper peptide technology for tissue remodeling studies GHK-Cu is a naturally occurring tripeptide-copper complex with documented effects on gene expression, collagen synthesis, and extracellular matrix remodeling in published literature

The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations