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This may lead to subsequent physiological abnormalities including gut dysbiosis and systemic inflammation, eventually resulting in a pathological clotting system, chronic endothelialitis, vasoconstriction, and hypoxia, as found in similar conditions such as heat stroke (183)

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The DURATION-1 and DURATION-5 clinical trials, which directly compared exenatide BID (Byetta) to exenatide QW (Bydureon), reported better HbA1c level reduction for Bydureon [119, 120]

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