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We monitor every 4 to 6 weeks during titration and adjust pace, dose, or therapy if side effects are not tolerable

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doi:10.1002/ana.10483 2

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The c-MET serves as an attractive therapeutic target in SCLC, as shown through small interfering RNA (siRNA) and selective prototype c-MET inhibitor SU11274, inhibiting the phosphorylation of c-MET itself and its downstream molecules such as AKT, S6 kinase, and ERK1/2

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