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Acta Pol Pharm 67(3):21723 Di Meo S, Reed TT, Venditti P, Victor VM (2016) Role of ROS and RNS sources in physiological and pathological conditions

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Studies also show that insulin alone cannot effectively manage diabetes because it doesn't address glucagon's catabolic effects, whereas treatments targeting glucagon suppression, such as leptin or glucagon receptor antibodies, could lead to better glucose regulation

For instance, a salt could dissociate differently at the injection site, which may lead to changes in absorption rate compared to the drug used during the original drug development process