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Contact your GP or IBD team promptly if you experience any of the following whilst taking weight loss injections: Severe or persistent abdominal pain, particularly if different from your usual Crohn's symptoms Significant worsening of diarrhoea or new-onset bloody stools Persistent vomiting preventing adequate fluid or medication intake Signs of dehydration (dark urine, dizziness, reduced urination) Unexplained fever or signs of infection Severe constipation or inability to pass wind (potential obstruction) Symptoms suggesting pancreatitis (severe upper abdominal pain radiating to the back) stop the medication immediately and seek urgent medical attention For severe symptoms, contact NHS 111 for urgent advice or go to A&E/call 999 if you experience severe abdominal pain with vomiting, inability to pass stool or wind, or signs of severe dehydration

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Nucleosome A subunit of chromatin that is composed of DNA wrapped around a tetramer of histone proteins

MicroScale thermophoresis (MST) MST experiments were performed using a Monolith NT.115 instrument (Red/Blue, NanoTemper Technologies GmbH, Munich, Germany) following the manufacturers standard protocols