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Unlike GHRH analogues (such as Sermorelin or CJC-1295) which act at the GHRH receptor via cyclic AMP-dependent signalling, Ipamorelin triggers rapid GH release through GHS-Rmediated pathways at the hypothalamus and anterior pituitary

2014;9(2):e88956

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These effects reflect the GI slowing caused by delayed gastric emptying and tend to resolve as the body adapts to the compound

Digestive side effects like vomiting or diarrhea can pull magnesium and potassium lower, and there is some evidence these medications can reduce iron levels