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However, we mitigated potential unmeasured confounding effects by employing proxy variables, (e.g., DCSI was used for diabetes severity and obesity surgery was used to identify morbidly obese patients)

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Third, it upregulates VEGFR2 and activates the VEGFR2-Akt-eNOS pathway, accelerating blood vessel formation and blood flow recovery in ischaemic tissue, a mechanism confirmed in endothelial cell culture and rat hind-limb ischaemia models by Hsieh 2017

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