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Some have reported that serum MMA and homocysteine levels increase with age and the prevalence of elevated MMA and homocysteine levels is higher than the prevalence of low vitamin B 12 or clinically evident vitamin B 12 deficiency in the elderly.19 20 21 22 In this regard, using the assay for metabolites alone may result in overdiagnosis and overtreatment

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Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years