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For researchers interested in potential cognitive or neurological effects , nasal delivery may offer advantages over systemic injection

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(2002a)

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Comparison to Other Routes Intravenous: 100% bioavailability (by definitionthe full dose enters circulation) Subcutaneous: Likely 6090% bioavailability (depends on absorption rate) Oral: ~38% systemic bioavailability This is why some researchers hypothetically prefer injected routeshigher bioavailability means lower nominal doses are needed