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Dr Martin Juneau, M.D., FRCP Cardiologue, directeur de l'Observatoire de la prvention de l'Institut de Cardiologie de Montral

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Quick Answer If semaglutide isn't producing weight loss results, the seven most common reasons are: (1) dose not optimized, (2) body has adapted (tolerance/plateau), (3) hidden hormonal resistance (thyroid, insulin, cortisol), (4) stress and poor sleep, (5) nutrition quality issues, (6) muscle loss and low activity, and (7) underlying medical conditions or interfering medications