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Furthermore, angiotensin IIstimulating antihypertensives, e.g., ARBs, exhibited lower dementia risk than angiotensin II inhibiting antihypertensives, e.g., ACE inhibitors (van Dalen et al., 2021)

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Clinical evidence suggests that the incidence and prevalence of IHD generally increase with age 8 alongside other contributing factors such as hypertension, diabetes mellitus, dyslipidemia, and smoking 9

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In macrophages, the activation of mGluR5 elevates the level of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) g and promotes a shift from M1 to M2 phenotype, leading to reduced IFN- production [180]