In rodents, -cell replication increased by 2.8-fold after partial pancreatectomy [4] and by 2.5-fold during pregnancy [5]
Our analysis supports these warnings being lifted, especially for semaglutide and liraglutide, which have been studied in large-scale, diverse population treatment-emergent (TE) crossover studies
The funders had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript
The effects of GLP-1 RA on BMI In five studies, changes in BMI were reported among 873 participants, with 444 using GLP-1 RA and 429 non-users
These effects typically diminish with continued use and can be minimized through gradual dose titration and administration with meals