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In some embodiments, otic formulations or compositions described herein increase the bioavailability and/or steady state levels of a drug in auris structures (e.g., in inner ear and/or the endolymph and/or the perilymph)

Balkrishna A, et al

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Therefore, COX-1 is thought to be the dominant source of prostanoids for housekeeping functions and COX-2 is considered to be a main source in inflammation, although platelet-derived prostanoids generated through COX-1 are linked to promotion of an inflammatory state [59, 6365]