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El estudio SELECT, realizado con SEMA 2,4mg, mostr coherentemente una reduccin de eventos cardiovasculares adversos mayores (major adverse cardiac events [MACE]) de triple objetivo compuesto (infarto de miocardio no mortal, accidente cerebrovascular no mortal, mortalidad cardiovascular) del 20% respecto a placebo en una poblacin con enfermedad cardiovascular establecida e IMC superior a 27kg/m2 sin diabetes tras 39,8meses de seguimiento23

Conclusions Approximately half of type 2 diabetes patients who had started using GLP-1 receptor agonists or SGLT2 inhibitors had discontinued treatment within 5 years of follow-up

The trade-off is cost (substantial) and a real side-effect profile

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los programas clnicos posteriores evalan la misma entidad en poblaciones y desenlaces definidos