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1999, plasma half-life approximately two hours after intravenous administration in healthy male volunteers) measured growth hormone release as the sole pharmacodynamic readout and did not measure plasma cortisol, ACTH, or prolactin in humans [4]

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GHRH receptor signaling Tesamorelin activates a Gs-coupled receptor on pituitary somatotrophs, increasing adenylate cyclase, cyclic AMP, protein kinase A signaling, GH synthesis, and GH release