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When the inflammatory burden is high from insulin resistance, dyslipidemia (high LDL/triglycerides), high blood pressure, and liver stress it drives cholesterol particles into the artery lining and triggers the plaque buildup that can eventually rupture and cut off blood flow to the heart

The published preclinical work (Neelakantan et al., referenced via PMC5826726) reported clean safety at 20 mg/kg subcutaneous in mice over 11 days

This process of AMPK activation is the link to berberines benefits for diabetic patients, as well as other conditions like obesity and high cholesterol

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