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Importantly, co-treatment with ML162 and PEG further improved functional restoration in the early phase

During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)

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The reaction mechanism differs between individual GPx isoforms, whose activity requires GSH

By influencing enzymes involved in fat storage and breakdown, CLA can help reduce body fat while preserving muscle tissue, making it a popular choice for those aiming to improve body composition