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For the last two decades, skeletal muscle was the main target of therapy [40], and drug discovery programs focused on strategies to inhibit the muscle catabolic pathways and stimulate the anabolic pathways [52]

A Model for Changes in MRS Measured Glutamate, GABA, and Glutamine Levels During the Progression of ALS The purpose of this section is to present a model for relating mechanisms of pathogenesis in ALS to fluxes and concentrations quantifiable by MRS

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