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Metabolism of Purine Bases, Nucleosides and Alkaloids in Theobromine-Forming Theobroma Cacao Leaves

Excitability Measurements of electrical activity (action potentials) in the isolated cardiac myocytes showed no significant change in the major parameters of action potential: the maximal slope of depolarization ( V max ) and action potential duration (APDs corresponding to repolarization levels of 20%, 50%, and 90%

Kinetic assays showed that rifampicin significantly induced CYP3A4 activity in iHLOs over three days, while ketoconazole consistently suppressed CYP3A4 activity over the same period (Fig

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