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The D-Nle~Trp- Ile-NH-(CH 2 )5-CONH 2 analog, which exhibits intermediate inhibition of dimerization, predictably has a moderate affinity for HGF and a moderate ability to inhibit HGF-dependent processes (Figures 25, 26, 27)

2006;84(4):76273 Available from: Kuria A, Tian H, Li M, Wang Y, Aaseth JO, Zang J, et al

Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Engen et al., 2020) (Figure 10)

Sharma, S., & Tripathi, P