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Patient heterogeneity further complicates translation: HFpEF is frequently associated with systemic metabolic dysfunction, whereas HFrEF often reflects ischemic or toxic injury

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Zhais team (Zhai et al., 2020) found that exendin-4, a GLP-1 receptor agonist, enhances eNOS activity and NO production, which helps relax retinal capillaries and restore microvascular perfusion in ischemia-reperfusion (I/R) injury models

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Menstruation does not reduce semaglutide's effectiveness or alter how your body processes the medication