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Senescent cells secrete a toxic mix of inflammatory cytokines, proteases, and growth factors called the Senescence-Associated Secretory Phenotype (SASP)

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Notably, different drugs and herbals like pioglitazone, salmeterol, and curcumin hinder the degeneration of dopaminergic neurons in the SN by inhibiting NF-B which is involved in the progression of neuroinflammation and injury of dopaminergic neurons (Flood et al

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