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Description

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In hypoxic pulmonary hypertension (HPH), elevated CUL5 expression binds TRAF6 (TNF receptor-associated factor 6), activating the NF-B pathway to stabilize HIF-1, thereby increasing VEGF expression and driving pulmonary vascular remodeling and HPH progression (137), exerts its anti-endothelial effects in normal endothelial cells through CUL5-dependent mechanisms

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