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Retrieved 12 November 2023

Critically, these decidualization and matrix remodeling defects do not occur in isolation: they frequently co-occur with immune dysregulation, suggesting that RIF may represent a syndrome of coordinated endometrial dysfunction rather than a single-pathway failure [287, 297]

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The MTHFD1 gene is located on chromosome 14q23.3 and is composed of 28 exons that generate two alternatively spliced mRNAs that encode distinct protein isoforms

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