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NRF2 expression was markedly decreased in NSC-34 motor neuron cells transfected with the human SOD1 G93A gene, leading to significantly increased levels of MDA, GSH, and ROS, along with reduced expression of SLC7A11 and GPX4

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Moderate cardio and strength training can also increase glutathione levels while improving overall health

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doi: 10.3389/fphar.2026.1755175 Received 26 November 2025 Revised 21 January 2026 Accepted 20 February 2026 Published 09 March 2026 Volume 17 - 2026 Edited by Roland Bcker, Charit University Medicine Berlin, Germany Reviewed by Mark Lloyd Dapar, Central Mindanao University, Philippines Kishor Jain, Sinhgad Institutes, India Updates Copyright 2026 Kayesh, Kohara and Tsukiyama-Kohara