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demonstrated that disturbed flow activates the protein kinase, AMP-activated, alpha 1 (PRKAA1)/AMP-activated protein kinase 1 (AMPK1)-hypoxia-inducible factor (HIF)-glycolysis axis that supports EC proliferation, and inhibition of PRKAA1 accelerates atherosclerosis in ApoE / mice [41]

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Sean Hashmi, MD, is the regional medical director of Lifestyle & Obesity Medicine for the Southern California Permanente Medical Group, and national chair of the interregional clinical practice group for Lifestyle & Obesity Medicine, The Permanente Federation.

Acute pancreatitis has been observed in patients being treated with medicines like semaglutide