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Agron Res

The results are expressed as mean SEM

Activation of the PI3K/Akt pathway upregulates the expression of key osteogenic genes such as Runx2 , ALP , and COL1 , and promotes the synthesis of bone matrix proteins, thereby enhancing osteoblastic function and bone formation ( Additionally, oxidative stress and cellular damage frequently arise within the osteogenic microenvironment, posing challenges to osteoblast survival

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FDA-approved medications including naltrexone, acamprosate, and disulfiram significantly reduce craving intensity and frequency when prescribed by a physician as part of a treatment plan