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Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

The cohort had mean age of 45.5 (Standard deviation [SD], 12.9) years, mean BMI of 37.4 (SD, 6.8) kg/m2, 68.7% were female, and 66.8% were White

SURMOUNT-4: the maintenance question Perhaps the most important trial for long-term users

FIGURE 10 The excipients only exert their activity at high concentration, which means that, while they are able to prevent proteolysis as soon as they are released from the capsule, peristaltic action and dilution with luminal fluid result in reduction of their inhibitory activity after a certain time windowprobably no longer than 30 minutes