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These findings underscore the need for companies to adjust their strategies, possibly focusing on premium products that offer higher quality and better nutritional value despite reduced volumes

According to the MHRA-approved SmPC, gastrointestinal symptoms are the most frequently reported adverse effects, occurring in a significant proportion of patients, particularly during dose escalation

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Our studies also eliminate the possibility that enterocyte-derived DPP-4, accounting for about 90% of gut DPP-4, is the pool responsible for glucose- and lipid-lowering effects of either gut-selective or systemic doses of DPP4i

Increased thirst, frequent urination, or other signs of glucose dysregulation should prompt testing and evaluation