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Quick Answer: Feeling cold on Wegovy is often caused by a combination of rapid fat loss (losing insulation), a lower caloric intake (less fuel for heat), and the medications effect on the hypothalamus, which regulates body temperature

Sources FDA briefing document for the July 23-24, 2026 Pharmacy Compounding Advisory Committee meeting Official explanation of the 503A evaluation criteria, substances reviewed, and FDAs pre-meeting proposals