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Torres F, Gonzalez-Candia A, Montt C, et al

SARS-Cov-2 virus infection may initiate a strong inflammatory and dysregulated reaction in the lung with increased levels of IL-6 and a cytokine-storm (129) which has been shown to provoke either an asymptomatic, mild, or severe infections This cytokine dysregulation may be associated with neutrophil extracellular traps (130) and alterations in T cell activity (131)

In unstimulated cells, NF-B dimers are usually inactive and held in the cytoplasm by small inhibitory molecules from the NF-B inhibitory proteins family [107]

Perillo B, Di Donato M, Pezone A, Di Zazzo E, Giovannelli P, Galasso G, et al