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A decrease in red blood cell concentration (reflected in the hematocrit) will cause whole blood concentration to fall without a change in pharmacologically active concentrations

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In cancer cells, high concentration of NO can damage various macromolecules such as nucleic acids and proteins and finally trigger apoptosis

Background Inadequate consumption of animal food and pernicious anaemia (loss of intrinsic factor due to autoimmune atrophic gastritis) are the most common causes of severe vitamin B12 deficiency worldwide in children and adults