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PubMed Central, Niwa, Y., et al

Dietary quality improvements, increased physical activity, and better sleep can all improve insulin sensitivity and reduce visceral fat independently of changes in overall body weight

In either case, because of the decreased activity of this enzyme and insufficient production of NADPH under stress, the cell's ability to recycle GSSG to GSH is impaired, and drug-induced oxidative stress leads to excessive damage and lysis of RBCs (hemolysis) and hemolytic anemia